Vascular Effects of Intermittent Hypoxia
نویسندگان
چکیده
منابع مشابه
Uncoupling of Vascular Nitric Oxide Synthase Caused by Intermittent Hypoxia
Objective. Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is often present in diabetic (DB) patients. Both conditions are associated with endothelial dysfunction and cardiovascular disease. We hypothesized that diabetic endothelial dysfunction is further compromised by CIH. Methods. Adult male diabetic (BKS.Cg-Dock7m +/+ Leprdb /J) (db/db) mice (10 weeks old...
متن کاملHypoxia-inducible factor-1α and vascular endothelial growth factor in the cardioprotective effects of intermittent hypoxia in rats
OBJECTIVE This study investigated the effects of short-term intermittent hypoxia (IH) preconditioning on cardiac structure and function in rats and the influence of ischemia reperfusion (I/R) injury. Special attention was then paid to the involvement of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF). METHODS Wistar rats were given IH treatment for 1, 7, 14,...
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The acute effects of inspiration of 100 percent oxygen on .the uterine vascular beds of castrated and pregnant ewes were evaluated in a chronic conscious preparation. In castrated ewes, vascular conductance decreased to 90.8 f 17.9 S. D. percent of control levels. During pregnancy, no significant changes in conductance occurred. The results suggest that acute maternal hyperoxia causes essential...
متن کاملIntermittent hypoxia and neurorehabilitation.
In recent years, it has become clear that brief, repeated presentations of hypoxia [i.e., acute intermittent hypoxia (AIH)] can boost the efficacy of more traditional therapeutic strategies in certain cases of neurologic dysfunction. This hypothesis derives from a series of studies in animal models and human subjects performed over the past 35 yr. In 1980, Millhorn et al. (Millhorn DE, Eldridge...
متن کاملIntermittent hypoxia has organ-specific effects on oxidative stress.
Obstructive sleep apnea is characterized by upper airway collapse, leading to intermittent hypoxia (IH). It has been postulated that IH-induced oxidative stress may contribute to several chronic diseases associated with obstructive sleep apnea. We hypothesize that IH induces systemic oxidative stress by upregulating NADPH oxidase, a superoxide-generating enzyme. NADPH oxidase is regulated by a ...
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ژورنال
عنوان ژورنال: ILAR Journal
سال: 2009
ISSN: 1084-2020
DOI: 10.1093/ilar.50.3.282